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Cannabinoids Modulate Synaptic Activity in the Rat Supraoptic Nucleus
Author(s) -
Soya A.,
Serino R.,
Fujihara H.,
Onaka T.,
Ozaki Y.,
Saito T.,
Nakamura J.,
Ueta Y.
Publication year - 2005
Publication title -
journal of neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.062
H-Index - 116
eISSN - 1365-2826
pISSN - 0953-8194
DOI - 10.1111/j.1365-2826.2005.01350.x
Subject(s) - supraoptic nucleus , excitatory postsynaptic potential , inhibitory postsynaptic potential , neurotransmission , am251 , chemistry , neuroscience , cannabinoid , cannabinoid receptor , postsynaptic potential , agonist , medicine , endocrinology , biology , receptor , hypothalamus , biochemistry
Abstract In the present study, we investigated the effects of the cannabinoid receptor agonist CP55,940 on excitatory and inhibitory synaptic transmission in the rat supraoptic nucleus. Whole‐cell patch clamp recordings were performed on supraoptic neurones in in vitro brain slice preparations. CP55,940 significantly reduced the frequency of spontaneous excitatory and inhibitory postsynaptic currents in a concentration‐dependent manner. These changes were potently reversed by the CB1 receptor antagonist AM251. The results indicate that cannabinoids modulate the activity of magnocellular neurosecretory neurones by presynaptic inhibition of both excitatory and inhibitory synaptic transmission.