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Blood pressure in diabetic nephropathy – current controversies
Author(s) -
Ritz E.,
Rychlík I.,
Schömig M.,
Wagner J.
Publication year - 2001
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2001.00791.x
Subject(s) - medicine , diabetic nephropathy , blood pressure , proteinuria , nephropathy , diabetes mellitus , endocrinology , urology , intensive care medicine , kidney
Abstract. Ritz E, Rychlík I, Schömig M, Wagner J (Department of Internal Medicine, Ruperto Carola University, Heidelberg, Germany). Blood pressure in diabetic nephropathy – current controversies (Review). J Intern Med 2001; 249: 215–223. Hypertension has been recognized as an early and constant feature of diabetic nephropathy, but recent studies also suggest that a genetic predisposition to hypertension is an important risk factor for diabetic nephropathy. Antihypertensive treatment attenuates progression in diabetic nephropathy, but there is increasing evidence that very early treatment and very low target blood pressures should be implemented. There is also evidence for local activation of the renin system in the kidney as a result of hyperglycaemia. Apart from blood pressure, proteinuria should be monitored and dosing of ACE inhibitors should be guided, also by reduction of protein excretion.