Premium
Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention
Author(s) -
Laakso M.
Publication year - 2001
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2001.00789.x
Subject(s) - medicine , diabetes mellitus , type 2 diabetes , blood pressure , endocrinology , disease , aspirin , macrovascular disease , risk factor , obesity
. Laakso M (University of Kuopio, Kuopio, Finland). Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention (Review). J Intern Med 2001; 249: 225–235. Type 2 diabetes increases the risk of cardiovascular disease (CVD) two‐ to fourfold compared with the risk in non‐diabetic subjects. Although type 2 diabetes is associated with a clustering of risk factors (small, dense low‐density lipoprotein [LDL] particles, low high‐density lipoprotein [HDL] cholesterol, high triglycerides, elevated blood pressure, obesity, central obesity, hyperinsulinaemia, hyperglycaemia, etc.), the cause for an excess risk of CVD remains unknown. Recent drug treatment trials have indicated that the lowering of total and LDL cholesterol and blood pressure is similarly beneficial in diabetic and non‐diabetic subjects. The treatment of hyperglycaemia reduces micro‐ and macrovascular complications in type 2 diabetic patients. Beta‐blocking agents, angiotensin‐converting enzyme inhibitors, aspirin, and thrombolytic therapy are also effective in the treatment of CVD amongst diabetic patients.