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A prospective study of menopause in women with Down's syndrome
Author(s) -
Seltzer G. B.,
Schupf N.,
Wu H.S.
Publication year - 2001
Publication title -
journal of intellectual disability research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 104
eISSN - 1365-2788
pISSN - 0964-2633
DOI - 10.1111/j.1365-2788.2001.00286.x
Subject(s) - menopause , medicine , logistic regression , proportional hazards model , prospective cohort study , premature menopause , surgical menopause , gynecology , demography , gerontology , sociology
The present study prospectively examined the age at menopause of 92 women with Down's syndrome (DS) and the influence of hypothyroidism on the age of menopause. Three methods were used to determine the distribution and median age at onset of menopause: (1) Kaplan–Meier life tables; (2) Cox proportional hazards modelling; and (3) maximum likelihood logistic regression. All three methods provided distributions and similar estimates of the median age at menopause, which was ≈46 years. The presence of hypothyroidism did not influence age at menopause. The earlier‐than‐expected age at onset of menopause suggests that women with DS are at an increased risk for post‐menopausal health disorders.