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Towards microbiological quality assurance in radiation sterilization processing: the limiting case model applied to a microbial population having a distribution of radiation responses
Author(s) -
Dwyer J.,
Fitch F.R.,
Doolan P.T.,
Dwyer V.M.,
Halls N.A.,
Tallentire A.
Publication year - 1985
Publication title -
journal of applied bacteriology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.889
H-Index - 156
eISSN - 1365-2672
pISSN - 0021-8847
DOI - 10.1111/j.1365-2672.1985.tb03320.x
Subject(s) - quality assurance , limiting , sterilization (economics) , radiation , population , environmental science , medicine , business , engineering , physics , operations management , environmental health , mechanical engineering , optics , external quality assessment , exchange rate , foreign exchange market , finance
A limiting case model, developed earlier to provide a conservative estimate of the proportion of non‐sterile items ( P ) in an irradiated population of items contaminated with micro‐organisms of a single type, has been extended to include items having organisms of different types. Estimates of P are compared with exact values derived on purely theoretical grounds and with values obtained by computer simulation of microbiological inactivation on items.