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Erythropoietin is involved in angiogenesis in human primary melanoma
Author(s) -
Ribatti Domenico,
Nico Beatrice,
Perra Maria Teresa,
Longo Vito,
Maxia Cristina,
Annese Tiziana,
Piras Franca,
Murtas Daniela,
Sirigu Paola
Publication year - 2010
Publication title -
international journal of experimental pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.671
H-Index - 72
eISSN - 1365-2613
pISSN - 0959-9673
DOI - 10.1111/j.1365-2613.2010.00731.x
Subject(s) - angiogenesis , erythropoietin receptor , erythropoietin , paracrine signalling , cancer research , melanoma , receptor , neovascularization , medicine , endocrinology , biology
Summary In this study, the extent of angiogenesis, evaluated as microvascular volume density, immunoreactivity of tumour cells to erythropoietin (Epo) and of endothelial cells to Epo receptor (EpoR) have been correlated in human primary melanoma specimens. Results showed that Epo/EpoR expression correlate with angiogenesis and tumour thickness. These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis.