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CD45: all is not yet crystal clear
Author(s) -
Holmes Nick
Publication year - 2006
Publication title -
immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.297
H-Index - 133
eISSN - 1365-2567
pISSN - 0019-2805
DOI - 10.1111/j.1365-2567.2005.02265.x
Subject(s) - protein tyrosine phosphatase , receptor tyrosine kinase , phosphatase , kinase , biology , tyrosine kinase , microbiology and biotechnology , signalling , tyrosine , phosphorylation , signal transduction , biochemistry
Summary CD45 has been recognized as an important player in regulating signalling in lymphocytes. However, compared with tyrosine kinases, phosphatases are still poorly understood in terms of the details of their specificity and regulation. Here, the recent progress in understanding the biology of the first recognized receptor tyrosine phosphatase, CD45, is reviewed.