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Bcl‐2 and BLIMP‐1 expression predict worse prognosis in gastric diffuse large B cell lymphoma (DLCBL) while other markers for nodal DLBCL are not useful
Author(s) -
MartinArruti Maialen,
Vaquero Manuel,
Díaz de Otazu Ramón,
Zabalza Iñaki,
Ballesteros Javier,
Roncador Giovanna,
GarcíaOrad Africa
Publication year - 2012
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.2011.04160.x
Subject(s) - diffuse large b cell lymphoma , lymphoma , immunohistochemistry , nodal , germinal center , pathology , medicine , oncology , b cell , immunology , antibody
Martin‐Arruti M, Vaquero M, Díaz de Otazu R, Zabalza I, Ballesteros J, Roncador G & García‐Orad A
(2012) Histopathology 60, 785–792 Bcl‐2 and BLIMP‐1 expression predict worse prognosis in gastric diffuse large B cell lymphoma (DLCBL) while other markers for nodal DLBCL are not useful Aims: Previous studies have identified clinicopathological and immunohistochemical differences among diffuse large B cell lymphomas (DLBCL) as a function of disease location. Nevertheless, there is a continuing tendency to generalize the prognostic value of various identified markers without taking into account tumour site. Accordingly, we analysed the prognostic value of several of the immunohistochemical markers that have been proposed for nodal DLBCL in a group of patients with gastric DLBCL. Methods and results: Using histochemical methods, CD10, Bcl‐6, Gcet1, MUM‐1, Bcl‐2 and BLIMP‐1 expression was investigated in 43 cases of gastric DBLCL. As in nodal DLBCLs, expression of BLIMP‐1, and of Bcl‐2 in non‐germinal centre B cell‐like (non‐GCB) patients, was associated with a worse prognosis. However, unlike nodal DBLCL, there was no significant association of prognosis with expression of CD10, Bcl‐6, Gcet1 or MUM‐1, or with categorization according to Hans or Muris algorithms. Conclusions: Although most markers of prognosis in nodal DLBCL are not useful indicators for gastric DLBCL, Bcl‐2 or BLIMP‐1 expression does correlate with worse prognosis. These data support the notion that clinicopathological features in DLBCL vary according to the disease location.