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Expression of the Ig‐associated heterodimer (mb‐1 and B29) in Hodgkin's disease
Author(s) -
KUZU I.,
DELSOL G.,
JONES M.,
GATTER K.C.,
MASON D.Y.
Publication year - 1993
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1993.tb00092.x
Subject(s) - disease , cancer research , medicine , biology , microbiology and biotechnology , pathology
Eighty‐three cases of Hodgkin's disease were studied immunocytochemically for the presence of the Ig associated heterodimer (mb‐1 and B29) which is believed to be a specific pan B‐cell marker. These results were compared with those achieved using other B‐cell markers against CD19, CD20 and CD22. Although a small number of cases of nodular sclerosis and mixed cellularity subtype showed positivity for CD19, CD20 or CD22, no case showed any reactivity with antibodies against mb‐1 or B29. This contrasted markedly with the cases of lymphocyte predominance where all seven cases expressed one or more of the B‐cell antigens, with six cases being positive for mb‐1. These results confirm previous studies that have suggested lymphocyte‐predominance Hodgkin's disease is of B‐cell origin and different from the other subtypes. However, they do not provide support for the thesis that these other subtypes may also have a B‐cell origin, albeit with a different phenotype to lymphocyte predominance.