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Immunoglobulin deposits in the biliary remnants of extrahepatic biliary atresia: a study by immunoperoxidase staining in 128 infants
Author(s) -
HADCHOUEL M.,
HUGON R. N.,
ODIEVRE M.
Publication year - 1981
Publication title -
histopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.626
H-Index - 124
eISSN - 1365-2559
pISSN - 0309-0167
DOI - 10.1111/j.1365-2559.1981.tb01779.x
Subject(s) - biliary atresia , immunoperoxidase , pathology , staining , medicine , extrahepatic biliary atresia , antibody , gastroenterology , immunology , monoclonal antibody , liver transplantation , transplantation
Bile duct remnants taken from 128 infants during surgery for extrahepatic biliary atresia were paraffin embedded prior to immunoperoxidase staining. Immunoglobulin deposits were found in 44 remnants. They were made up of IgM alone in 25 cases and of IgM and IgG in 19. Deposits were observed along the basement membranes of glandular structures. These findings suggest that extrahepatic bilary atresia might be an acquired and evolving disease.