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Blood‐brain barrier permeability of L‐dopa in man
Author(s) -
FRII M. L.,
PAULSON O. B.,
HERTZ M. M.,
BOLWIG T. G.
Publication year - 1981
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1981.tb01845.x
Subject(s) - permeability (electromagnetism) , blood–brain barrier , chemistry , carbidopa , chromatography , dilution , medicine , levodopa , biochemistry , central nervous system , physics , disease , membrane , parkinson's disease , thermodynamics
. The permeability of L‐dopa across the blood‐brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [l‐ 14 C]L‐dopa and [3‐ 14 C]L‐dopa was 11.7% and 10.4%, respectively. After pretreatment with carbi‐dopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient ( P ) was calculated to 0.9×10 ‐5 cm s ‐1 .