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Fibronectin in synovial fluid and tissue in rheumatoid arthritis
Author(s) -
VARTIO TAPIO,
VAHERI ANTTI,
ESSEN ROBERT VON,
ISOMÄKI HEIKKI,
STENMAN SVANTE
Publication year - 1981
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1981.tb01842.x
Subject(s) - fibronectin , rheumatoid arthritis , synovial fluid , synovial membrane , connective tissue , basement membrane , chemistry , glycoprotein , pathology , arthritis , medicine , extracellular matrix , immunology , osteoarthritis , biochemistry , alternative medicine
Abstract . Fibronectin is a glycoprotein found in body fluids, loose connective tissue matrix and in basement membranes. Fibronectin in rheumatoid arthritis synovial fluid was immunologically indistinguishable from the plasma form, as shown by double‐diffusion analysis. Fibronectin isolated from rheumatoid synovial fluid by affinity chromatography on gelatin‐Sepharose had a polypeptide pattern similar to that of plasma fibronectin in SDS‐polyacrylamide gel electrophor‐esis. In fifty‐one patients with rheumatoid arthritis and related diseases fibronectin concentrations in synovial fluid were 445 ±103 μg/ml (mean ±SD) and within normal range, 335±52 μg/ml, in plasma. Immuno‐fluorescence staining showed a prominent increase of fibronectin in the proliferating synovial connective tissue in rheumatoid arthritis as compared to normal synovial membrane. The results suggest an increased local production of fibronectin in rheumatoid synovial tissue.