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Consequences of misdiagnosis of lymphomatoid papulosis
Author(s) -
LAUBE S.,
SHAH F.,
MARSDEN J.
Publication year - 2006
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/j.1365-2354.2005.00632.x
Subject(s) - medicine , lymphomatoid papulosis , pathological , radiation therapy , dermatology , chemotherapy , lymphoma , pathology , surgery , radiology , mycosis fungoides
We report two patients with lymphomatoid papulosis (LyP), who were initially diagnosed as systemic T‐cell lymphoma. The patients presented with recurrent self‐healing cutaneous lesions and skin biopsies showed a lymphocytic infiltrate with malignant features. Clinico‐pathological correlation of findings was not performed and results of staging investigations were misinterpreted. Consequently, both patients were unnecessarily treated with multi‐agent chemotherapy, radiotherapy and stem cell/bone marrow transplants and sustained long‐term adverse effects. The clinical and histological features of LyP are described and appropriate management discussed in detail. Factors leading to the unnecessary treatment of both patients are examined and several learning points highlighted such as the importance of a multidisciplinary approach.