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Correlation between ovarian steroids and lipid fractions in relation to age in premenopausal women
Author(s) -
Brideau NatalieAnne,
Forest JeanClaude,
Lemay André,
Dodin Sylvie
Publication year - 1992
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1992.tb02356.x
Subject(s) - endocrinology , medicine , menstrual cycle , testosterone (patch) , apolipoprotein b , body mass index , cholesterol , chemistry , biology , hormone
OBJECTIVE We evaluated the effect of sex steroids on the lipid fractions (cholesterol, triglycerldes, LDL‐C, HDL‐C and subtractions HDL 2 ‐C and HDL 3 ‐C) and on the apollpo‐proteins (A‐I and B) in relation to age in women. DESIGN Twenty‐eight normally cycling women belonging to three age groups (20–29, n = 11; 30–39, n = 10; 40–49, n = 7) had blood samples taken dally during one cycle. MEASUREMENTS Serum lipld fractions, apollpoprotelns (Apo) and ovarian steroids were measured daily during the menstrual cycle. Diet and exercise were also evaluated. RESULTS Each age group had comparable profiles for dally serum concentrations of oestradiol, progesterone and testosterone. There were no significant variations of the lipid fractions or of the ApoA‐I and ApoB during the menstrual cycle in each group. Using regression analysis, modifications of cholesterol, triglycerides, LDL‐C and ApoB were partially but significantly correlated with age. These changes occurred in spite of similar serum concentrations of oestradiol, progesterone and testosterone in the three groups. Lipld fractions were also affected by the increase of body mass index with age, especially HDL‐C and HDL 2 C. However, there were no differences in lipld and energy intake or in energy expenditure during physical leisure activities. CONCLUSIONS These results indicate that physiological fluctuations of ovarian steroids have no effects on llplds and Apo in normally cycling women of increasing age. In this study, the age related changes in the lipld fractions were partially correlated with body mass index but not with energy intake or exercise.