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LHRH TEST IN BARTTER'S SYNDROME BEFORE AND DURING TREATMENT WITH PROSTAGLANDIN SYNTHESIS INHIBITORS
Author(s) -
LARIZZA DANIELA,
LORINI RENATA,
CISTERNINO MARIANGELA,
SALVATONI A.,
SEVERI FRANCESCA
Publication year - 1981
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1981.tb00661.x
Subject(s) - endocrinology , medicine , basal (medicine) , bartter's syndrome , prostaglandin , endogeny , bartter syndrome , chemistry , diabetes mellitus , hypokalemia
SUMMARY LHRH tests were performed in two children with Bartter's syndrome before and during treatment with prostaglandin synthesis inhibitors. Before treatment, in patient 1 both basal and peak FSH and LH levels were elevated; in patient 2 basal and peak FSH levels were above the normal range, while basal and peak LH levels were normal. During treatment with an inhibitor of prostaglandin synthesis, abnormal values decreased into the normal range. These results support a possible role of endogenous prostaglandins in regulating gonadotrophin secretion in humans.