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IN VITRO BIOSYNTHESIS OF 1 8‐HYDROXY‐l l‐DEOXYCORTI‐COSTERONE FROM DEOXYCORTICOSTERONE BY HUMAN ADRENAL GLANDS REMOVED FROM PATIENTS WITH HYPERCORTICISM
Author(s) -
TOUITOU Y.,
BOGDAN A.,
LUTON JP.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb03044.x
Subject(s) - medicine , adrenocortical carcinoma , endocrinology , biosynthesis , in vitro , adrenalectomy , adenoma , cushing syndrome , hyperplasia , incubation , adrenal adenoma , chemistry , enzyme , biochemistry
SUMMARY The biosynthesis of 18‐hydroxy‐ll‐deoxycorticosterone (18‐OH‐DOC) was studied by in vitro incubations of human adrenals resected from patients with Cushing's syndrome, using deoxycorticosterone as precursor. 18‐OH‐DOC synthesis was similar in adrenals from normal subjects and in those derived from patients with different types of Cushing's syndrome (hyperplasia, adenoma, carcinoma). The in vitro addition of o,p'‐DDD (5 X 10 ‐3 M) to an adrenocortical carcinoma incubation did not alter 18‐OH‐DOC biosynthesis. By contrast, treatment of the patient with o,p'‐DDD prior to adrenalectomy resulted in a low production of 18‐OH‐DOC in vitro but only when cortisol synthesis was drastically decreased.
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