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SELECTIVE INHIBITORY EFFECT OF PORCINE FOLLICULAR FLUID ON FOLLICLE STIMULATING HORMONE SECRETION IN ANTERIOR PITUITARY CELLS IN CULTURE
Author(s) -
LAGACÉ LISETTE,
LABRIE FERNAND,
LORENZEN JANICE,
SCHWARTZ NEENA B.,
CHANNING CORNELIA P.
Publication year - 1979
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1979.tb02095.x
Subject(s) - medicine , endocrinology , follicular fluid , anterior pituitary , secretion , incubation , gonadotropin , inhibitory postsynaptic potential , basal (medicine) , follicle stimulating hormone , chemistry , follicular phase , gonadotropic cell , hormone , pituitary gland , luteinizing hormone , biology , oocyte , embryo , biochemistry , insulin , microbiology and biotechnology
SUMMARY Incubation of rat anterior pituitary cells in culture with porcine follicular fluid (treated with charcoal to remove steroids) led to a marked inhibition of spontaneous FSH release while no effect was observed on basal LH secretion. The inhibitory effect of follicular fluid was, however, less specific on LHRH‐induced gonadotropin release. Although more potent on FSH than LH release, a significant inhibition of LH release induced by the neurohormone was also observed. This inhibitory activity is mainly associated with material of MW 10000 daltons.