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EFFECTS OF GROWTH HORMONE RELEASE‐INHIBITING HORMONE AND BROMOCRYPTINE (CB 154) IN STATES OF ABNORMAL PITUITARY‐ADRENAL FUNCTION
Author(s) -
BENKER G.,
HACKENBERG K.,
HAMBURGER B.,
REINWEIN D.
Publication year - 1976
Publication title -
clinical endocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 147
eISSN - 1365-2265
pISSN - 0300-0664
DOI - 10.1111/j.1365-2265.1976.tb02831.x
Subject(s) - endocrinology , medicine , hormone , growth hormone , pituitary gland , adrenocorticotropic hormone
Growth hormone release‐inhibiting hormone (GHR‐IH) was administered to five patients with abnormal pituitary‐adrenal function. There was immediate suppression by about 50% of ACTH levels in two patients who had undergone bilateral adrenalectomy because of Cushing's disease; one of them had Nelson's syndrome. Bromocryptine (2.5 mg) suppressed ACTH levels by 62‐67% for more than 6 h in these patients GHR‐IH did not significantly influence cortisol secretion by an adrenal carcinoma and only slight changes were seen in two patients with Addison's disease. The possible therapeutic implications are discussed.