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Efficacy of narrowband ultraviolet B twice weekly for hypopigmented mycosis fungoides in Asians
Author(s) -
Kanokrungsee S.,
Rajatanavin N.,
Rutnin S.,
Vachiramon V.
Publication year - 2012
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.2011.04197.x
Subject(s) - mycosis fungoides , discontinuation , medicine , dermatology , regimen , ultraviolet b , complete response , methoxsalen , lymphoma , chemotherapy , psoriasis
Summary Hypopigmented mycosis fungoides (MF) is a rare variant of cutaneous T‐cell lymphoma. To date, there have been no data published about the efficacy of a twice‐weekly regimen of narrowband ultraviolet B (NB‐UVB) for the treatment of hypopigmented MF. We retrospectively reviewed 11 patients with hypopigmented MF who were treated with NB‐UVB twice weekly between 2001 and 2010. Of the 11 patients, 7 achieved a complete response with a mean of 40 treatments; the remaining 4 patients had a partial response. Upon discontinuation of treatment, three patients had clinical relapse after complete remission. Median time to relapse was 10 months. A twice‐weekly regimen of NB‐UVB is an effective treatment for hypopigmented MF with minimal side‐effects. However, the relapse rate is high, and unfortunately, no clinical or histological features can predict the relapse of the disease.