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Biometrological assessment of the preventive effect of a miconazole spray powder on athlete's foot
Author(s) -
PIÉRARD G.E.,
WALLACE R.,
DONCKER P.
Publication year - 1996
Publication title -
clinical and experimental dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.587
H-Index - 78
eISSN - 1365-2230
pISSN - 0307-6938
DOI - 10.1111/j.1365-2230.1996.tb00119.x
Subject(s) - miconazole , stratum corneum , medicine , foot (prosody) , adverse effect , trichophyton , dermatophyte , garlic powder , dermatology , pharmacology , antifungal , chemistry , pathology , raw material , linguistics , philosophy , organic chemistry
Summary Prevention of athlete's foot is a difficult problem. Using non‐invasive biometrological methods, we evaluated the changes induced in the stratum corneum by a 3‐week treatment with miconazole spray powder. A total of 16 athletes apparently at risk of developing tinea pedis, but without any evidence for the disease at the time of inclusion, participated in the study. They applied the medicated powder to one foot daily, while the other foot remained untreated to serve as a control. No adverse events occurred. In comparison with the control site, the capacitance of the toeweb skin was significantly reduced by the treatment. The ex vivo bioassay of dermatophyte culture on stratum corneum demonstrated a significant inhibition of growth of Trichophyton mentagropkytes var. interdigitale at the treated site. The results of this study provide indirect evidence that the regular use of miconazole spray powder decreases die risk of developing athlete's foot.