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Dynamics of mast cell degranulation in human allergic nasal epithelium after provocation with allergen
Author(s) -
KAWABORI S.,
OKUDA M.,
UNNO T.,
NAKAMURA A.
Publication year - 1985
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1985.tb02303.x
Subject(s) - provocation test , histamine , degranulation , nasal provocation test , allergen , allergy , mast cell , medicine , immunology , mucous membrane of nose , pathology , receptor , alternative medicine
Summary The histamine content in the nasal epithelial layer of twenty‐five patients with nasal allergy was measured before, 10 min after and 1 hr after nasal provocation with allergen. A decrease in histamine content was observed 10 min after provocation compared to the values obtained before provocation ( P <0.05). There was a tendency for an increase in the histamine content of the nasal epithelium one hour after provocation when compared with the amounts present 10 min after provocation ( P <0.1). Mast cells in the nasal epithelial layer of a further five patients were studied by electron microscopy 10 min and 1 hr after provocation. The rate of mast cell degranulation appeared to decrease 1 hr after provocation when compared with 10 min. Our study suggests that some mast cells commence their migration to the nasal epithelial layer over a short time period and that they may play a role in the onset of the allergic nasal reaction in patients with allergic nasal symptoms.