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Recurrent nocturnal asthma after bronchoprovocation with Western Red Cedar sawdust: association with acute increase in non‐allergic bronchial responsiveness
Author(s) -
COCKCROFT D. W.,
HOEPPNER V. H.,
WERNER G. D.
Publication year - 1984
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1984.tb02191.x
Subject(s) - asthma , medicine , nocturnal , bronchial hyperreactivity , asthma attack , allergy , immunology , respiratory disease , lung
Summary Recurrent nocturnal asthma following a single exposure to Western Red Cedar sawdust was documented by measurements of peak flow rates in two sensitized subjects. The nocturnal asthma followed a dual asthmatic response in the first subject and a late (non‐immediate) asthmatic response in the second. Both subjects developed a 10‐fold reduction in the dose of histamine required to decrease the FEV 1 by 20%. This cedar‐induced increase in non‐specific bronchial reactivity was maximal at the time of the recurrent nocturnal asthma, and persisted after nocturnal asthma had ceased and after FEV 1 had returned to normal. We hypothesize that the enhanced non‐specific bronchial reactivity which occurs following late asthmatic responses to bronchial challenge is the cause of recurrent nocturnal asthma following single exposure to a sensitizing agent.