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Intermediate α 1 ‐antitrypsin deficiency in atopic allergy
Author(s) -
HOFFMANN J. J. M. L.,
KRAMPS J. A.,
DIJKMAN J. H.
Publication year - 1981
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1981.tb02174.x
Subject(s) - atopy , allergy , medicine , asthma , immunology , population , alpha 1 antitrypsin deficiency , immunopathology , disease , environmental health
Summary In a population of over 200 patients with atopic bronchial disease, significantly increased frequencies of the α 1 ‐antitrypsin Pi‐types of intermediate deficiency (Pi MZ and Pi MS) were found. As far as we are aware of, this report is the first in which strictly objective criteria for patient classification with respect to atopy have been used. A possible biochemical basis for the phenomenon is presented.