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Oxatomide and exercise‐induced asthma in children: the value of serial exercise tests
Author(s) -
SILVERMAN M.,
TOOLEY MARION
Publication year - 1981
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1981.tb01614.x
Subject(s) - medicine , exercise induced asthma , asthma , physical exercise , physical therapy , value (mathematics) , cardiology , mathematics , statistics
Summary Two groups of eight asthmatic children carried out serial treadmill exercise tests at 2‐hourly intervals, after double‐blind premedication with oxatomide (2 mg/kg by mouth), sodium cromoglycate powder (20 mg by inhalation) or matched placebo preparations. The drugs were studied in one group up to 6 hr and in the other group (omitting sodium cromoglycate) from 4 to 10hr after administration. Peak expiratory flow rate was measured before and after exercise to give an index of exercise‐induced asthma. Oxatomide had a slight but significant bronchodilator effect. After a lag period of up to 4 hours, oxatomide exerted a significant protective effect against exercise‐induced asthma which lasted until at least 8 hr. At 10 hr after ingestion, the effect had gone. A mean maximum diminution of exercise‐induced asthma of 49% was found, in comparison with placebo. Oral oxatomide after a lag period, exerts a significant protective effect against exercise‐induced asthma. The relevance of these observations for the clinical management of asthma remains to be determined.