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Cell‐mediated immune reactions in asthma
Author(s) -
FARRERONSCO J.,
VELASCO M. FARRERONS,
PUIGGROS J. VIVES,
GARCÍA CALDERÓN P. A.
Publication year - 1978
Publication title -
clinical and experimental allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.462
H-Index - 154
eISSN - 1365-2222
pISSN - 0954-7894
DOI - 10.1111/j.1365-2222.1978.tb01497.x
Subject(s) - immunology , immunoglobulin e , immune system , antigen , asthma , medicine , population , in vivo , lymphocyte , immunopathology , biology , antibody , microbiology and biotechnology , environmental health
Summary Abnormally high levels of IgE are produced in various diseases, including atopic eczema, and a functional decrease in the T‐lymphocyte population occurs at the same time. T‐cell function has been studied in a group of asthma patients with high, normal and low IgE levels and in a control group. T‐cell function appears to be reduced in asthmatic patients with high concentrations of IgE when skin tests are performed with Candida antigen ( P <0.05). There was also a decline in the lymphocyte transformation tests with Candida antigen in autologous serum ( P <0.05), although not in foetal calf serum. The responses to in vivo tests with streptokinase‐streptodornase were normal, as was the response of the lymphocytes to PHA.