OPTIMIZED PARAMETERS FOR THE MITOTIC CYCLE | Zendy

Barrett John C. | Zendy

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OPTIMIZED PARAMETERS FOR THE MITOTIC CYCLE

Author(s) -

Barrett John C.

Publication year - 1970

Publication title -

cell proliferation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.647

H-Index - 74

eISSN - 1365-2184

pISSN - 0960-7722

DOI - 10.1111/j.1365-2184.1970.tb00342.x

Subject(s) - mitosis , monte carlo method , maximum likelihood , biological system , biology , mathematics , statistics , statistical physics , computer science , algorithm , physics , microbiology and biotechnology

A method is described for the maximum likelihood estimation of the six parameters representing the means and standard deviations of the phases G 1 , S and G 2 of the mitotic cycle. The likelihood is not explicitly formulated but is computed by the Monte Carlo program which evaluates the percentage of mitotic cells labelled with 3 H‐thymidine. The method is applied to data obtained from an experiment performed with transplanted Marshall rat mammary tumours.

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