Open AccessOPTIMIZED PARAMETERS FOR THE MITOTIC CYCLE
Author(s) -
Barrett John C.
Publication year - 1970
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/j.1365-2184.1970.tb00342.x
Subject(s) - mitosis , monte carlo method , maximum likelihood , biological system , biology , mathematics , statistics , statistical physics , computer science , algorithm , physics , microbiology and biotechnology
ABSTRACT A method is described for the maximum likelihood estimation of the six parameters representing the means and standard deviations of the phases G 1 , S and G 2 of the mitotic cycle. The likelihood is not explicitly formulated but is computed by the Monte Carlo program which evaluates the percentage of mitotic cells labelled with 3 H‐thymidine. The method is applied to data obtained from an experiment performed with transplanted Marshall rat mammary tumours.