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Monoclonal gammopathy of undetermined significance: a consensus statement
Author(s) -
Berenson James R.,
Anderson Kenneth C.,
Audell Robert A.,
Boccia Ralph V.,
Coleman Morton,
Dimopoulos Meletios A.,
Drake Matthew T.,
Fonseca Rafael,
Harousseau JeanLuc,
Joshua Douglas,
Lonial Sagar,
Niesvizky Ruben,
Palumbo Antonio,
Roodman G. David,
SanMiguel Jesus F.,
Singhal Seema,
Weber Donna M.,
Zangari Maurizio,
Wirtschafter Eric,
Yellin Ori,
Kyle Robert A.
Publication year - 2010
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2010.08207.x
Subject(s) - plasma cell dyscrasia , monoclonal gammopathy of undetermined significance , medicine , dyscrasia , statement (logic) , consensus conference , multiple myeloma , plasma cell , osteoporosis , intensive care medicine , pathology , monoclonal , immunology , monoclonal antibody , immunoglobulin light chain , antibody , political science , law
Summary On February 25, 2009, a panel of international experts on plasma cell dyscrasia and skeletal disease met to discuss monoclonal gammopathy of undetermined significance (MGUS). This non‐malignant B‐cell disorder is the most common plasma cell dyscrasia and is associated with an increased risk of developing serious B‐cell disorders. Individuals with MGUS also have an increased risk of osteoporosis and osteopenia associated with an increased likelihood of developing fractures especially in the vertebral column, peripheral neuropathy and thromboembolic events. The goal of the meeting was to develop a consensus statement regarding the appropriate tests to screen, evaluate and follow‐up patients with MGUS. The panel also addressed the identification and treatment of MGUS‐related skeletal problems, thromboembolic events and neurological complications. The following consensus statement outlines the conclusions and marks the first time that a consensus statement for the screening and treatment of MGUS has been clearly stated.