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Expression of the Rho‐family GTPase gene RHOF in lymphocyte subsets and malignant lymphomas
Author(s) -
Gouw Launce G.,
Scott Reading N.,
Jenson Stephen D.,
Lim Megan S.,
ElenitobaJohnson Kojo S. J.
Publication year - 2005
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2005.05481.x
Subject(s) - germinal center , biology , downregulation and upregulation , lymphocyte , b cell , lymphoma , follicular lymphoma , cancer research , gene expression , pathology , gene , microbiology and biotechnology , immunology , genetics , medicine , antibody
Summary We have studied the expression of RHOF , a member of the Rho‐GTPase family, in an array of lymphoid cells and tissues. Previous microarray studies demonstrated RHOF upregulation in a subset of transformed follicular lymphomas. Real‐time quantitative polymerase chain reaction evaluated RHOF expression in lymphocyte subpopulations, and normal and malignant lymphoid tissue. Cells and tissues of B‐cell origin expressed higher RHOF levels than their T‐cell counterparts. Neoplastic cells and tissues of B‐cell origin expressed higher levels of RHOF than their benign cellular counterparts. Relatively elevated levels of RHOF were seen in lymphomas derived from germinal centre origin.