Premium
Clearance of coagulation factor VIII in very low‐density lipoprotein receptor knockout mice
Author(s) -
Bovenschen Niels,
Dijk Ko Willems,
Havekes Louis M.,
Mertens Koen,
Vlijmen Bart J. M.
Publication year - 2004
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2004.05093.x
Subject(s) - knockout mouse , in vivo , ldl receptor , lipoprotein , catabolism , medicine , chemistry , endocrinology , receptor , coagulation , biology , cholesterol , metabolism , microbiology and biotechnology
Summary Low‐density lipoprotein receptor‐related protein (LRP) contributes to factor VIII (FVIII) catabolism in vivo . Besides LRP, FVIII also interacts with very low‐density lipoprotein receptor (VLDLR) in vitro . We investigated the physiological role of VLDLR in FVIII catabolism, using knockout mouse models for VLDLR and LRP, alone and in combination. VLDLR −/− mice displayed normal plasma FVIII, whereas VLDLR −/− LRP − double‐knockout mice had slightly increased FVIII compared with LRP‐deficient mice. Remarkably, VLDLR deficiency slightly accelerated FVIII clearance. Adenovirus‐mediated overexpression of VLDLR did not lower plasma FVIII in LRP‐deficient mice. We conclude that VLDLR does not act in concert with LRP in FVIII clearance in vivo .