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Hypofibronectinaemia and severity of sickle cell anaemia in Nigeria
Author(s) -
Emeribe A. O.,
Udoh A. E.,
Etukudoh M. H.,
Okany C. C.,
Kehinde M.,
Catty D.,
Raykundalia C.
Publication year - 2000
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.2000.02445.x
Subject(s) - nigerians , fibronectin , medicine , immunology , cell , sickle cell anemia , anemia , gastroenterology , disease , biology , biochemistry , political science , law
Plasma fibronectin levels in sickle cell anaemia and apparently healthy Nigerians were investigated to determine any correlation with disease severity. A cheaper in‐house plasma fibronectin assay was also developed that could be adapted for use in Africa and elsewhere. Plasma fibronectin assay was concurrently carried out using the newly developed inhibition enzyme‐linked immunosorbent assay (ELISA) and a commercial competitive binding ELISA. The in‐house assay compared favourably with that of the commercial kit. The mean plasma fibronectin levels in sickle cell anaemia subjects were significantly lower than that of control subjects ( P < 0·001). Plasma fibronectin concentration could therefore be useful in assessing the severity of sickle cell anaemia.