Premium
Relationship between megakaryocyte mass and serum thrombopoietin levels as revealed by a case of cyclic amegakaryocytic thrombocytopenic purpura
Author(s) -
Zent Clive S.,
Ratajczak Janina,
Ratajczak Mariusz Z.,
Anastasi John,
Hoffman Philip C.,
Gewirtz Alan M.
Publication year - 1999
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1999.01351.x
Subject(s) - thrombopoietin , megakaryocyte , megakaryocytopoiesis , thrombocytopenic purpura , platelet , medicine , haematopoiesis , immunology , endocrinology , biology , stem cell , microbiology and biotechnology
Cyclic amegakaryocytic thrombocytopenic purpura is a rare syndrome characterized by periodic failure of megakaryocytopoiesis. In this report we describe a patient with cyclic amegakaryocytic thrombocytopenic purpura associated with a megakaryocyte specific serum IgG antibody, who responded to cyclosporin A therapy. Serial serum thrombopoietin assays during an episode of platelet cycling demonstrated a reciprocal relationship between serum thrombopoietin level and megakaryocyte mass, suggesting that megakaryocytes have an important role in the regulation of thrombopoietin metabolism.