Premium
A specific chromosome abnormality of t(4;12)(qll‐12;pl3) in CD7 + acute leukaemia
Author(s) -
HARADA HIRONORT,
ASOU HIROYA,
KYO TAIICHL,
ASAOKU HIDEKI,
IWATO KOJI,
DOHY HIROO,
ODA KENJI,
HARADA YUKA,
KITA KENKICHI,
KAMADA NANAO
Publication year - 1995
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1995.tb05206.x
Subject(s) - immunophenotyping , bone marrow , pathology , chromosomal translocation , haematopoiesis , biology , cd34 , myeloperoxidase , cytogenetics , dysplasia , chromosome abnormality , immunology , karyotype , chromosome , medicine , stem cell , flow cytometry , genetics , inflammation , gene
Summary. Three cases of acute leukaemia with t(4;12) (qll‐12;pl3) karyotypic abnormalities were analysed. They had the following common clinical and biological characteristics: (1) dysplasia of three haemopoietic lineages; (2) absent or low myeloperoxidase activity; and (3) retention of platelets in the peripheral blood and megakaryocytes in the bone marrow. There were increased numbers of basophils in the bone marrow and peripheral blood in two of the cases. In all, the blast cells displayed the unique immunophenotype CD7 + CD13 + CD34 + HLA‐DR + . The blasts analysed in one case expressed c‐kit on the membrane surface. These findings suggest that the t(4:12) (qll‐12:pl3) abnormality is associated with a particular type of acute leukaemia, one in which the morphology and immunophenotype suggest that the translocation may have occurred at an early stage of haemopoiesis.