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The effects of gestation on circulating progenitor cells
Author(s) -
Jones H. M.,
Nathrath M.,
Thomas R. M.,
Edelman P.,
Rodeck C. H.,
Linch D. C.
Publication year - 1994
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1994.tb08329.x
Subject(s) - gestation , fetus , erythropoietin , progenitor cell , peripheral blood mononuclear cell , medicine , endocrinology , cord blood , andrology , umbilical cord , biology , pregnancy , stem cell , immunology , in vitro , biochemistry , genetics
Summary The frequency of BFU‐E in second‐trimester fetal blood (484 ± 104/10 5 ) falls progressively during gestation to a value of 69 ± 41/10 5 in cord bloods of 36 weeks gestation and beyond, but this is still significantly greater than adult blood values of 14 ± 8 (P < 0.01). BFU‐E obtained from unfractionated peripheral blood mononuclear cells from fetuses/neonates less than 36 weeks gestation were more sensitive to erythropoietin than adult BFU‐E, but the sensitibvity of highly purified BFU‐E obtained from secondtrimester fetal liver was similar to that in adult cells. Almost maximal growth of BFU‐E from purified fetal progenitor cells could be achieved with erythropoietin alone, whereas adult cells required the presence of other factors with ‘burstpromoting activity’.