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Interferon therapy for chronic non‐A non‐B and chronic delta liver disease in haemophilia
Author(s) -
Lee Christine A.,
Kernoff P. B. A.,
Karayiannis P.,
Thomas H. C.
Publication year - 1989
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1989.tb07688.x
Subject(s) - haemophilia , medicine , chronic liver disease , disease , interferon , alpha interferon , chronic disease , immunology , liver disease , pediatrics , cirrhosis
Summary. The case histories of a carrier of haemophilia A with chronic post transfusion non‐A non‐B hepatitis and a severe haemophiliac with chronic delta hepatitis are described. Therapy with lymphoblastoid alpha interferon resulted in improvement of NANB and HDV related chronic hepatitis and resolution of HIV related thrombocytopenia. Interferon may modulate replication of more than one transfusion transmitted virus in the haemophiliac.