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The role of platelet membrane glycoproteins Ib and IIb‐IIIa in platelet adherence to human artery subendothelium
Author(s) -
Sakariassen Kjell S.,
Nievelstein Patricia F. E. M.,
Coller Barry S.,
Sixma Jan J.
Publication year - 1986
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1986.tb07552.x
Subject(s) - platelet , platelet membrane glycoprotein , glycoprotein , medicine , membrane glycoproteins , chemistry , biochemistry
S ummary Platelet adherence to human artery subendothelium in blood from eight normal subjects, four patients with Glanzmann's thrombasthenia (deficiency of platelet membrane glycoproteins IIb and IIIa: GPIIb‐IIIa), two patients with Bernard‐Soulier syndrome (deficiency of platelet membrane glycoprotein Ib: GPIb) and one patient with von Willebrand's disease (VWD subtype III, deficient in factor VHI‐von Willebrand factor: FVIII‐VWF) was compared at various wall shear rates (300, 500, 1000, 1800 and 2500 s ‐1 ).