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Endothelial cell proliferation in myelofibrosis
Author(s) -
Reilly J. T.,
Nash J. R. G.,
Mackie M. J.,
McVerry B. A.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb07465.x
Subject(s) - laminin , myelofibrosis , bone marrow , staining , basement membrane , pathology , chemistry , biology , immunology , cell , medicine , biochemistry
S ummary The distribution of laminin and collagen type IV in normal human bone marrow appeared to be limited to a small number of capillary and sinusoidal basement membranes. Cellular elements including megakaryocytes showed a negative staining reaction. In contrast, myelofibrotic bone marrow showed markedly increased quantities of both laminin and collagen type IV. This was consistent with a proliferation of endothelial cells within the marrow as confirmed by factor VIII RAG staining. It is suggested that in myelofibrosis in addition to a marked fibrous reaction proliferation of vascular elements is also prominent.