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Reduced thromboplastin activity in blood monocytes and reduced sensitivity to stimuli in vitro of blood monocytes from pregnant women
Author(s) -
ØIan P.,
Omsjø I.,
Maltau J. M.,
ØSterud B.
Publication year - 1985
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1985.tb02973.x
Subject(s) - medicine , thromboplastin , fibrinogen , partial thromboplastin time , prekallikrein , monocyte , endocrinology , prothrombin time , pregnancy , immunology , platelet , coagulation , chemistry , biology , kallikrein , enzyme , biochemistry , genetics
S ummary. The thromboplastin activity in blood monocytes from 18 normal third trimester pregnant women has been compared with a group of 20 healthy non‐pregnant women. The thromboplastin activity in unstimulated monocytes from the normal pregnant group was on average 40% of the activity in the non‐pregnant group (P<0.01). In endotoxin stimulated monocytes, the thromboplastin activity was also significantly lower in the pregnant group as compared to the non‐pregnant group (P <0.001). Fibrinogen and factors V, VII and VIII were significantly higher in the pregnant than in the non‐pregnant group, whereas no difference was observed in AT‐III, prekallikrein and α 2 ‐antiplasmin levels.