A chronic myeloproliferative disorder associated with monosomy 7 in the bone marrow cells; normal karyotype in acute transformation | Zendy

Linch D. C. | Zendy; Walker H. | Zendy; Roberts P. | Zendy; McKin J. | Zendy; Goldstone A. H. | Zendy; Huehns E. R. | Zendy

Premium

A chronic myeloproliferative disorder associated with monosomy 7 in the bone marrow cells; normal karyotype in acute transformation

Author(s) -

Linch D. C.,

Walker H.,

Roberts P.,

McKin J.,

Goldstone A. H.,

Huehns E. R.

Publication year - 1982

Publication title -

british journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.907

H-Index - 186

eISSN - 1365-2141

pISSN - 0007-1048

DOI - 10.1111/j.1365-2141.1982.00439.x

Subject(s) - karyotype , monosomy , bone marrow , myeloproliferative disorders , abnormality , medicine , pathology , immunology , biology , chromosome , genetics , psychiatry , gene

S ummary . A chronic myeloproliferative disorder associated with monosomy 7 of the bone marrow cells is described in a male infant. After nearly 4 years, during which time no drug therapy was given, the disease transformed to a ‘blast crisis’ and at this stage the karyotypes of the marrow and unstimulated blood cells were shown to be normal. It is proposed that the development of the myeloproliferative disorder associated with monosomy 7 is a multistage process and the acquisition of the chromosomal abnormality is a secondary event.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research