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Immunological Classification of Acute Lymphoblastic Leukaemias: Evaluation of its Clinical Significance in a Hundred Patients
Author(s) -
Brouet JeanClaude,
Valensi Françoise,
Daniel MarieThérèse,
Flandrin Georges,
Preud'homme JeanLouis,
Seligmann Maxime
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03547.x
Subject(s) - medicine , incidence (geometry) , lymphoblastic leukemia , t cell , antigen , immunology , gastroenterology , leukemia , immune system , physics , optics
S ummary . The use of T and B lymphocyte markers and of different antisera raised against malignant B cells and fetal thymocytes allowed the classification of 100 patients with acute lymphoblastic leukaemia (ALL) into three groups. (1) Patients with non‐T non‐B ALL whose cells were devoid of conventional B and T markers but characterized by a leukaemia associated antigen (69 cases). (2) Patients with T‐derived ALL (28 cases). (3) Patients with ALL of B cell origin (three cases). The search for haematological and clinical correlations showed that those patients with T‐derived ALL tended to have a higher leucocyte count ( P = 0.05) and acid phosphatase positivity of blast cells ( P = 0.01), a higher incidence of tumour presentation ( P = 0.05) and a thymic mass. Survival curves for the two main groups of patients are similar at 36 months but meningeal relapses were more frequent in patients with T‐derived ALL ( P = 0.02).