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Blast Crisis of Chronic Myeloid Leukaemia (CML): I. PRESENTATION SIMULATING ACUTE LYMPHOID LEUKAEMIA (ALL)
Author(s) -
Beard M. E. J.,
Durrant Jill,
Catovsky D.,
Wiltshaw E.,
Amess J. L.,
Brearley R. L.,
Kirk Barbara,
Wrigley P. F. M.,
Janossy G.,
Greaves M. F.,
Galton D. A. G.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00188.x
Subject(s) - chronic myeloid leukaemia , blast crisis , medicine , philadelphia chromosome , myeloid , myeloid leukaemia , immunology , chromosomal translocation , biology , gene , biochemistry
SUMMARY. Seven patients presenting as an acute leukaemia caused difficulty in diagnosis. The lymphoid appearance of the blast cells either initially or during treatment suggested acute lymphoid leukaemia (ALL). In each case the Philadelphia chromosome was shown to be present thus suggesting that these cases were examples of chronic myeloid leukaemia (CML) presenting in blast crisis without a detectable chronic phase. The implications of these findings are discussed and the difficulty in achieving a precise diagnosis in the acute leukaemias is emphasized. Cytogenetic analysis should be carried out whenever the type of acute leukaemia present is of critical importance.