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Complete response of deep neutrophilic dermatosis associated with myelodysplastic syndrome to 5‐azacytidine
Author(s) -
Raj K.,
Ho A.,
Creamer J.D.,
Du Vivier A.W.P.,
Salisbury J.R.,
Mufti G.J.
Publication year - 2007
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.2007.07831.x
Subject(s) - myelodysplastic syndromes , medicine , azacitidine , refractory (planetary science) , bone marrow , disease , complete remission , refractory anemia , premalignant lesion , dermatology , immunology , chemotherapy , cancer , biology , biochemistry , gene expression , astrobiology , dna methylation , gene
Summary Cutaneous manifestations of myelodysplastic syndromes (MDS) may predict disease progression and a poorer prognosis. We describe a patient in whom a deep neutrophilic dermatosis preceded evolution of disease from refractory anaemia to RAEB (refractory anaemia with excess blasts) and resolved completely on treating the disease with 5‐azacytidine. The dermatological response was accompanied by complete bone marrow remission and trilineage haematological improvement. We suggest that 5‐azacytidine should be considered in the treatment of immune mediated cutaneous manifestations of MDS.