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A comparison of 2 weeks of terbinafine 250 mg/day with 4 weeks of itraconazole 1OO mg/day in plantar‐type tinea pedis
Author(s) -
HAY R.J.,
McGREGOR J.M.,
WUITE J.,
RYATT K.S.,
EGLER C.Z.,
CLAYTON Y.M.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb08718.x
Subject(s) - terbinafine , itraconazole , medicine , statistical significance , dermatophyte , dermatology , antifungal , surgery
Summary This double‐blind, parallel group study compared a 2‐week course of terbinafine 250 mg/day with a 4‐week course of itraconazole 100 mg/day. A total of 190 patients were enrolled, of whom 129 were evaluable for efficacy. At week 8, 69% of patients treated with terbinafine were classified as effectively treated (mycological cure, and clinical assessment total score ≤2) vs. 67% in the itraconazole group. At week 16, however, the rating for effective treatment increased to 71% of the terbinafine group, but decreased to 55% of the itraconazole group. This difference was of borderline statistical significance ( P = 0.06). The results of this study demonstrate that both drugs can be used safely, and that 2 weeks' treatment with terbinafine 250 mg daily is as effective as 4 weeks' treatment with itraconazole 100 mg daily, but with fewer long‐term relapses.