Cutaneous infiltration in T‐cell prolymphocytic leukaemia

Summary T‐cell prolymphocytic leukaemia (T‐PLL) is an aggressive leukaemia accounting for over 30% of all mature T‐cell malignancies. We describe the clinical manifestations and histology of cutaneous involvement in a series of 92 patients with T‐PLL. Of the 92 patients. 26 (28%) had cutaneous involvement, and in 23 this was present at the time of the diagnosis of the leukaemia. Skin manifestations included a diffuse infiltrated erythema, infiltration localized to the face and ears, nodules and erythroderma. Histology showed a perivascular and periappendageal dermal infiltrate of lymphoid cells with the morphology of prolymphocytes. An early skin biopsy in these patients should help to reveal the underlying diagnosis.