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Expression of ICAM‐3/CD50 in normal and diseased skin
Author(s) -
MONTAZERI A.,
KANITAKIS J.,
ZAMBRUNO G.,
BOURCHANY D.,
SCHMITT D.,
CLAUDY A.
Publication year - 1995
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1995.tb02664.x
Subject(s) - dermis , icam 1 , immune system , biology , cell adhesion molecule , immunology , pathology , immunohistochemistry , langerhans cell , medicine , anatomy
Summary ICAM‐3 is a newly recognized adhesion molecule, which is a member of the immunoglobulin supergene family of ICAMs. and has been shown to be identical with the CD50 antigen. Recent functional studies have shown that ICAM‐3 is a ligand for LFA‐1, and plays an important part in immune reactions. To date, very few data exist in the literature concerning its expression in the skin. In the present study, we investigated the expression of ICAM‐3 in normal skin and in 98 biopsy specimens of various inflammatory and neoplastic dermatoses. ICAM‐3 was found to be expressed by epidermal CD la + Langerhans cells, by cells of Langerhans cell hisliocytosis, by T and B lymphocytes infiltrating the dermis in cutaneous lymphomas and in a wide spectrum of inflammatory dermaloses. Epidermal keralinocytes were consistently negative: endothelial expression of ICAM‐3 was observed in six of the 48 cases. These results show that ICAM‐3 is constitutively and widely expressed by cells participating in inflammatory dermaloses (including Langerhans cells and T and B lymphocytes), and that it can be albeit rarely, induced on endothelial cells and dermal dendrocytes. These results highlight the important part that ICAM‐3 may play in cutaneous inflammatory and immune reactions.