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Is epidermal cell proliferation in psoriatic skin grafts on nude mice driven by T‐cell derived cytokines?
Author(s) -
BAKER B.S.,
BRENT L.,
VALDIMARSSON H.,
POWLES A.V.,
ALIMARA L.,
WALKER M.,
FRY L.
Publication year - 1992
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1992.tb07805.x
Subject(s) - psoriasis , infiltration (hvac) , transplantation , pathology , medicine , epidermis (zoology) , keratinocyte , immunology , biology , cell culture , anatomy , physics , genetics , thermodynamics
Summary Plasminogen activity and DNA synthesis by epidermal cells have been reported to be doubled in psoriatic skin grafts compared with grafts of normal skin 6 weeks after transplantation to nude mice. In our study human lymphocytes disappeared from such grafts within 48 h whilst some DR‐positive human dendritic cells were retained in the grafts for up to 4 weeks. However, the grafts were infiltrated by Thy 1.2 + mouse lymphocytes within 6 days and this infiltration persisted at a moderate level throughout the observation period. It consisted of perivascular aggregates, scattered dermal and papillary T cells, and some mouse T cells were also found in the epidermal compartment. Grafts of psoriatic and non‐psoriatic control skin were infiltrated to a similar extent, suggesting a low‐grade rejection response against the human xenografts. These findings raise the possibility that psoriatic keratinocytes are responding abnormally to inflammatory cytokines released by mouse lymphocytes reacting against the skin grafts.