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Adult mastocytosis: an immunophenotypic and flow‐cytometric investigation
Author(s) -
ORMEROD A.D.,
HERRIOT R.,
DAVIDSON R.J.L.,
SEWELL H.F.
Publication year - 1990
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1990.tb06260.x
Subject(s) - immunophenotyping , medicine , cutaneous mastocytosis , systemic mastocytosis , dermatology , flow cytometry , pathology , immunology , bone marrow
summary Skin mast cells of five patients with mastocytosis/urticaria pigmentosa and from four normal controls were immunophenotyped with a panel of 17 monoclonal antibodies; peripheral blood mononuclear cells from the patients were similarly labelled and analysed by flow cytometry. Cutaneous mast cells expressed leucocyte common antigen and markers of macropahe/ monocyte lineage suggesting a common progenitor in the ontogeny of the two cell types. The mast cells from the patients differed from the controls, expressing HLA‐DR in four cases, and this may be a feature of proliferating cells. The patients' peripheral blood T lymphocytes showed a marked increase in the activation markers HLA‐DR and CD 25 suggesting a contributory role, possibly via cytokines, in driving mast‐cell proliferation.