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Anti‐nuclear RNP antibodies in two sisters
Author(s) -
SHIIKI H.,
MIYAGAWA S.,
DOHI K.,
YAMADA H.,
HANATANI M.,
ISHIKAWA H.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02388.x
Subject(s) - antibody , immunology , haplotype , human leukocyte antigen , medicine , pathology , biology , antigen , genetics , allele , gene
SUMMARY Two sisters with clinical elements of mixed connective tissue disease were found to have anti‐nuclear RNP (nRNP) antibodies. These antibodies were not found in the six other family members examined. The sisters had inherited an identical HLA haplotype A2‐BW61CW3‐DR1 from their mother who had had Raynaud's phenomenon for several years. Analysis of peripheral lymphocyte subsets in the patients and their immediate relatives showed decreased OKT‐4‐positive cells in one of the patients and increased OKT‐8‐positive cells in both patients, their father and their brother, resulting in lower OKT 4/OKT 8 ratios in these members of the family. This is the third description of the familial occurrence of anti‐nRNP antibodies and it adds further evidence for the implication of genetic factors in the development of anti‐nRNP antibodies.