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The thin layer rapid use epicutaneous test (TRUE‐test), a new patch test method with high accuracy
Author(s) -
FISCHER T.I.,
MAIBACH H.I.
Publication year - 1985
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1985.tb02292.x
Subject(s) - patch test , bioavailability , test (biology) , thin layer , test method , materials science , layer (electronics) , chromatography , mathematics , chemistry , medicine , nanotechnology , immunology , pharmacology , allergy , statistics , biology , paleontology
SUMMARY The thin layer rapid use epicutaneous test (TRUE‐test) is a new patch test, in which the allergens are incorporated in a thin, flexible solid vehicle on a water impermeable backing. The vehicle shows good stability for allergens, which are crystallized, micronized or emulsified into a gel. The TRUE‐test produces an exact dosage, even surface spread and high bioavailability for the allergens. This solves the problems of low bioavailability, uncertain dosage and uneven surface distribution which are commonly seen when petrolatum is used as the vehicle.