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Excess granulation tissue responses associated with isotretinoin therapy
Author(s) -
ROBERTSON D.B.,
KUBIAK E.,
GOMEZ E.C.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb14152.x
Subject(s) - isotretinoin , granulation tissue , curettage , medicine , acne , pathology , granulation , stroma , dermatology , surgery , wound healing , physics , immunohistochemistry , classical mechanics
SUMMARY Multiple polypoid projections of granulation tissue developed in two patients receiving isotretinoin for acne. Histological study of the lesions revealed increased amounts of non‐sulphated acid mucopolysaccharides in the ground substance of the granulation tissue stroma. Complete resolution occurred following curettage with or without chemical cautery. The role of isotretinoin in the development of these lesions is discussed.