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The semi‐quantitative distribution of T 4 and T6 surface antigens on human Langerhans cells
Author(s) -
SCHMITT D.,
FAURE M.,
DAMBUYANTDEZUTTER C.,
THIVOLET J.
Publication year - 1984
Publication title -
british journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.304
H-Index - 179
eISSN - 1365-2133
pISSN - 0007-0963
DOI - 10.1111/j.1365-2133.1984.tb14148.x
Subject(s) - immunogold labelling , monoclonal antibody , antigen , antibody , langerhans cell , cell , chemistry , microbiology and biotechnology , distribution (mathematics) , biology , biochemistry , immunology , mathematical analysis , mathematics
SUMMARY We have used indirect immunogold electron microscopy to compare the respective density of cell membrane determinants revealed by OKT6 and OKT 4 monoclonal antibodies on normal human Langerhans cells (LC): 12·9 ± 3·5 gold granules were noted per cell section on OKT 4 ‐positive LC whereas 236·8 ± 23·5 granules were counted per cell section on OKT6‐reactive cells. These results confirm that human LC react with OKT 4 antibody and they demonstrate a marked quantitative difference on LC surface between the antigenic determinants recognized by OKT6 and OKT 4 antibodies.
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